Onder andere met: Brandon Routh (Clark Kent/Superman), Kate Bosworth (Lois Lane), Kevin Spacey (Lex Luthor), James Marsden (Richard White), Parker Posey (Kitty Kowalski), Frank Langella (Perry White), Sam Huntington (Jimmy Olsen), Eva Marie Saint (Martha Kent), Marlon Brando (Jor-El (archive footage)), Kal Penn (Stanford), Tristan Lake Leabu (Jason White), David Fabrizio (Brutus), Ian Roberts (Riley), Vincent Stone (Grant), Jack Larson (Bo the Bartender)