Onder andere met: Laura Linney (Erin Bruner), Tom Wilkinson (Father Moore), Campbell Scott (Ethan Thomas), Jennifer Carpenter (Emily Rose), Colm Feore (Karl Gunderson), Joshua Close (Jason), Kenneth Welsh (Dr. Mueller (as Ken Welsh)), Duncan Fraser (Dr. Cartwright), JR Bourne (Ray), Mary Beth Hurt (Judge Brewster), Henry Czerny (Dr. Briggs), Shohreh Aghdashloo (Dr. Adani), Steve Archer (Guy in Bar), Arlene Belcastro (Praying Woman #2), David Berner (Karl`s Corny #1)