Onder andere met: Rodney Dangerfield (Thornton Melon), Sally Kellerman (Dr. Diane Turner), Burt Young (Lou), Keith Gordon (Jason Melon), Robert Downey Jr. (Derek), Paxton Whitehead (Dr. Phillip Barbay), Terry Farrell (Valerie Desmond), M. Emmet Walsh (Coach Turnbull), Adrienne Barbeau (Vanessa), William Zabka (Chas), Ned Beatty (Dean Martin), Severn Darden (Dr. Borozini), Sam Kinison (Professor Terguson), Robert Picardo (Giorgio), Kurt Vonnegut Jr. (Kurt Vonnegut)