Onder andere met: Ioan Gruffudd (Mr. Fantastic / Reed Richards), Jessica Alba (Invisible Woman / Susan Storm), Chris Evans (Human Torch / Johnny Storm), Michael Chiklis (The Thing / Ben Grimm), Julian McMahon (Dr. Doom / Victor Von Doom), Kerry Washington (Alicia Masters), Andre Braugher (General Hager), Doug Jones (The Silver Surfer), Laurence Fishburne (The Silver Surfer (Voice)), Beau Garrett (Captain Frankie Raye)