Onder andere met: Brendan Fraser (Rick O'Connell), Jet Li (Emperor Han), Maria Bello (Evelyn O’Connell), Luke Ford (Alex O'Connell), John Hannah (Jonathan Carnahan), Michelle Yeoh (Zi Juan), Isabella Leong (Lin), Anthony Wong Chau-Sang (General Yang), Russell Wong (General Ming Guo), Liam Cunningham (Mad Dog Maguire), David Calder (Prof. Roger Wilson), Jessey Meng (Choi), Tian Liang (Li Zhou), Albert Kwan (Chu Wah)