Onder andere met: Chris Pine (James T. Kirk), Zachary Quinto (Spock), Leonard Nimoy (Spock Prime), Eric Bana (Nero), Bruce Greenwood (Pike), Karl Urban (Bones), Zoe Saldana (Uhura (as Zoë Saldana)), Simon Pegg (Montgomery Scott), John Cho (Sulu), Anton Yelchin (Chekov), Ben Cross (Sarek), Winona Ryder (Amanda Grayson), Chris Hemsworth (George Kirk), Jennifer Morrison (Winona Kirk), Rachel Nichols (Gaila)