Onder andere met: Jason Segel (Peter Bretter), Kristen Bell (Sarah Marshall), Mila Kunis (Rachel Jansen), Russell Brand (Aldous Snow), Bill Hader (Brian Bretter), Liz Cackowski (Liz Bretter), Maria Thayer (Wyoma), Jack McBrayer (Darald), Taylor Wily (Kimo), Davon McDonald (Dwayne the Bartender (as Da'Vone McDonald)), Steve Landesberg (Dr. Rosenbaum), Jonah Hill (Matthew the Waiter), Paul Rudd (Chuck), Kala Alexander (Greg), Kalani Robb (Helpful Hawaiian Waiter)