Onder andere met: Dave Chappelle (Thurgood Jenkins / Sir Smoke-a-Lot), Guillermo Díaz (Scarface), Jim Breuer (Brian), Harland Williams (Kenny Davis), Rachel True (Mary Jane Potman), Clarence Williams III (Samson Simpson), Laura Silverman (Jan), Tommy Chong (Squirrel Master), R.D. Reid (Scientist), Gregg Rogell (Pothead), Kevin Brennan (Pothead), Alice Poon (Supply Clerk), Rick Demas (Nasty Nate), David Bluestein (Jerry Garcia), Jacqueline Anderson (Henchwoman Delilah), Snoop Dogg (Scavenger Smoker), Stephen Baldwin (McGayver Smoker), Bob Saget (Cocaine Addict)