Onder andere met: Kurt Russell (R.J. MacReady), Wilford Brimley (Dr. Blair), T.K. Carter (Nauls), David Clennon (Palmer), Keith David (Childs), Richard Dysart (Dr. Copper), Charles Hallahan (Vance Norris), Peter Maloney (George Bennings), Richard Masur (Clark), Donald Moffat (Garry), Joel Polis (Fuchs), Thomas G. Waites (Windows), Norbert Weisser (Norwegian), Larry J. Franco (Norwegian), Nate Irwin (Helicopter Pilot), William Zeman (Pilot)