Onder andere met: Vincent Cassel (Jacques Mesrine), Ludivine Sagnier (Sylvie), Mathieu Amalric (François Besse), Gérard Lanvin (Charly Bauer), Samuel Le Bihan (Michel Ardouin), Olivier Gourmet (Commissioner Broussard), Anne Consigny (Mesrine’s advocate), Georges Wilson (Henri Lelièvre), Michel Duchaussoy (Pierre André Mesrine, Mesrine's father), Myriam Boyer (Mesrine’s mother)