Onder andere met: Lindsay Lohan (Cady Heron), Rachel McAdams (Regina George), Tina Fey (Ms. Norbury), Tim Meadows (Mr. Duvall), Amy Poehler (Mrs. George), Ana Gasteyer (Betsy Heron), Lacey Chabert (Gretchen Wieners), Amanda Seyfried (Karen Smith), Lizzy Caplan (Janis Ian), Daniel Franzese (Damian), Neil Flynn (Mr. Heron), Jonathan Bennett (Aaron Samuels), Rajiv Surendra (Kevin Gnapoor), Elana Shilling (Spelling Girl), Graham Kartna (Homeschooled Boy)