Onder andere met: Bruce Willis (James Cole), Madeleine Stowe (Kathryn Railly), Brad Pitt (Jeffrey Goines), Christopher Plummer (Dr. Goines), David Morse (Dr. Peters), Jon Seda (Jose), Frank Gorshin (Dr. Fletcher), Joseph Melito (Young Cole), Vernon Campbell (Tiny), Joey Perillo (Detective Franki), Bruce Kirkpatrick (Policeman), Frederick Strother (L.J. Washington), LisaGay Hamilton (Teddy), Felix Pire (Fale), Matt Ross (Bee), Joseph McKenna (Wallace)