Onder andere met: Chevy Chase (Clark Griswold), Beverly D'Angelo (Ellen Griswold), Anthony Michael Hall (Russell Griswold), Dana Barron (Audrey Griswold), Imogene Coca (Aunt Edna), Randy Quaid (Cousin Eddie), Eddie Bracken (Roy Walley), Brian Doyle-Murray (Kamp Komfort Clerk), Miriam Flynn (Cousin Catherine), James Keach (Motorcycle Cop), Eugene Levy (Car Salesman), Frank McRae (Grover), John Candy (Lasky), Christie Brinkley (The Girl in the Ferrari), Jane Krakowski (Cousin Vicki), John P. Navin Jr. (Cousin Dale), Christopher Jackson (Pimp), Randy Lowell (Wyatt Earp)