Onder andere met: Harrison Ford (Indiana Jones), Sean Connery (Professor Henry Jones), Denholm Elliott (Dr. Marcus Brody), Alison Doody (Dr. Elsa Schneider), John Rhys-Davies (Sallah), Julian Glover (Walter Donovan), River Phoenix (Young Indy), Michael Byrne (Vogel), Kevork Malikyan (Kazim), Robert Eddison (Grail Knight), Richard Young (Fedora), Alexei Sayle (Sultan), Alex Hyde-White (Young Henry (scenes deleted)), Paul Maxwell (Panama Hat), Isla Blair (Mrs. Donovan (as Mrs. Glover))