Onder andere met: Peter Cushing (Baron Victor Frankenstein), Veronica Carlson (Anna Spengler), George Pravda (Dr. Frederick Brandt/the Creature - Brain), Freddie Jones (Professor Richter/the Creature - Body), Simon Ward (Dr. Karl Holst), Thorley Walters (Inspector Frisch), Windsor Davies (Police Sergeant), Maxine Audley (Ella Brandt), Geoffrey Bayldon (Police Doctor), Colette O'Neil (Madwoman), Peter Copley (Principal)