Onder andere met: Peter Cushing (Baron Victor Frankenstein), Francis Matthews (Dr. Hans Kleve), Eunice Gayson (Margaret), Oscar Quitak (Karl, the "dwarf"), Michael Gwynn (Karl in his new body), John Welsh (Bergman), Lionel Jeffries (Fritz), Richard Wordsworth (Up Patient), Charles Lloyd Pack (President of the Medical Council), George Woodbridge (Janitor), Michael Ripper (Kurt)