Onder andere met: Logan Lerman (Charlie Kelmeckis), Emma Watson (Sam), Ezra Miller (Patrick), Mae Whitman (Mary Elizabeth), Paul Rudd (Mr. Anderson, Charlie's English teacher), Nina Dobrev (Candace Kelmeckis, Charlie's sister), Johnny Simmons (Brad), Erin Wilhelmi (Alice), Adam Hagenbuch (Bob), Kate Walsh (Mrs. Kelmeckis), Dylan McDermott (Mr. Kelmeckis), Melanie Lynskey (Aunt Helen), Joan Cusack (Dr. Burton), Zane Holtz (Chris Kelmeckis, Charlie's older brother), Reece Thompson (Craig, Sam's college boyfriend), Nicholas Braun (Ponytail Derek, Candace's boyfriend)