Onder andere met: Peter Cushing (Baron Victor Frankenstein), Shane Briant (Dr. Simon Helder), Madeline Smith (Sarah), David Prowse (the Creature), John Stratton (Asylum Director Adolf Klauss), Michael Ward (Transient), Elsie Wagstaff (Wild one), Norman Mitchell (Police Sergeant), Clifford Mollison (Judge), Philip Voss (Ernst), Charles Lloyd Pack (Professor Durendel), Bernard Lee (Tarmut, the Sculptor)