Onder andere met: Sam Riley (Sal Paradise / Jack Kerouac), Garrett Hedlund (Dean Moriarty / Neal Cassady), Kristen Stewart (Marylou / LuAnne Henderson), Amy Adams (Jane / Joan Vollmer), Tom Sturridge (Carlo Marx / Allen Ginsberg), Alice Braga (Terry / Bea Franco), Elisabeth Moss (Galatea Dunkel / Helen Hinkle), Danny Morgan (Ed Dunkle / Al Hinkle), Kirsten Dunst (Camille / Carolyn Cassady), Viggo Mortensen (Old Bull Lee / William S. Burroughs), Ximena Adriana (Oaxacan Girl), Sarah Allen (Vicki)