Onder andere met: Megan Fox (April O'Neil), Will Arnett (Vernon Fenwick), William Fichtner (Eric Sacks), Alan Ritchson (Raphael), Noel Fisher (Michelangelo), Pete Ploszek (Leonardo), Jeremy Howard (Donatello), Danny Woodburn (Splinter), Tohoru Masamune (Shredder), Whoopi Goldberg (Bernadette Thompson), Minae Noji (Karai), Abby Elliott (Taylor), Madison Mason (Councilman), Taran Killam (McNaughton), K. Todd Freeman (Dr. Baxter Stockman), Paul Fitzgerald (Dr. O'Neil), Malina Weissman (Young April O'Neil)