Onder andere met: Steve Carell (Gru / Dru (voice)), Kristen Wiig (Lucy (voice)), Trey Parker (Balthazar Bratt (voice)), Miranda Cosgrove (Margo (voice)), Dana Gaier (Edith (voice)), Nev Scharrel (Agnes (voice)), Pierre Coffin (Minions (voice)), Steve Coogan (Fritz / Silas Ramsbottom (voice)), Julie Andrews (Gru's Mom (voice)), Jenny Slate (Valerie Da Vinci (voice)), Andy Nyman (Clive the Robot (voice)), Adrian Ciscato (Niko (voice))