Onder andere met: Sally Hawkins (Elisa), Michael Shannon (Strickland), Richard Jenkins (Giles), Octavia Spencer (Zelda), Michael Stuhlbarg (Dimitri Mosenkov/Dr. Robert Hoffstetler), Nigel Bennett (Mihalkov), Lauren Lee Smith (Elaine Strickland), John Kapelos (Mr. Arzoumanian), Morgan Kelly , Doug Jones , Stewart Arnott , David Hewlett , Nick Searcy , Martin Roach (Brewster)