Onder andere met: Will Smith (Det. Del Spooner), Bridget Moynahan (Dr. Susan Calvin), Alan Tudyk (Sonny (stem en motion capture), Bruce Greenwood (Lawrence Robertson), James Cromwell (Dr. Alfred Lanning), Chi McBride (Lt. John Bergin), Shia LaBeouf (Farber), Fiona Hogan (V.I.K.I.), Terry Chen (Chin), Adrian L. Ricard (Granny)