Onder andere met: Ice Cube (XXX/Darius Stone), Samuel L. Jackson (Agent Augustus Gibbons), Willem Dafoe (Gen. George Octavius Deckert), Scott Speedman (Agent Kyle Steele), Peter Strauss (President James Sanford), Xzibit (Zeke), Michael Roof (Toby Lee Shavers), Sunny Mabrey (Charlie), Nona Gaye (Lola Jackson), John G. Connolly (Lt. Alabama `Bama` Cobb), Ramon De Ocampo (Agent Meadows), Barry Sigismondi (Bull), Michael Don Evans (Conductor), David Rountree (Agent), Ned Schmidtke (Gen. Jack Pettibone)