Onder andere met: Kate Beckinsale (Selene), Scott Speedman (Michael Corvin), Michael Sheen (Lucian), Shane Brolly (Kraven), Bill Nighy (Viktor), Erwin Leder (Singe), Sophia Myles (Erika), Robbie Gee (Kahn (as Robby Gee)), Wentworth Miller (Dr. Adam Lockwood), Kevin Grevioux (Raze), Zita Görög (Amelia), Dennis J. Kozeluh (Dignitary (as Dennis Kozeluh)), Scott McElroy (Soren), Todd Schneider (Trix), Sándor Bolla (Rigel)