Onder andere met: Bud Cort (John Doe Jersey), Barret Hackney (Stygian Triplet), Jared Pfennigwerth (Stygian Triplet), Kitao Sakurai (Stygian Triplet), George Carlin (Cardinal Ignatius Glick), Betty Aberlin (Nun), Matt Damon (Loki), Ben Affleck (Bartleby), Dan Etheridge (St. Stephen`s Priest), Linda Fiorentino (Bethany Sloane), Derek Milosavljevic (Kissing Man), Lesley Braden (Kissing Woman), Marie Elena O`Brien (Clinic Girl (scenes deleted)), Brian O`Halloran (Grant Hicks (as Brian Christopher O`Halloran)), Janeane Garofalo (Liz), Alanis Morissette (God), Salma Hayek (Serendipity), Kevin Smith (Silent Bob), Jason Mewes (Jay), Chris Rock (Rufus), Jason Lee (Azrael)