Onder andere met: Jim Carrey (Joel Barish), Kate Winslet (Clementine Kruczynski), Gerry Robert Byrne (Train Conductor), Elijah Wood (Patrick), Thomas Jay Ryan (Frank), Mark Ruffalo (Stan), Jane Adams (Carrie), David Cross (Rob), Kirsten Dunst (Mary), Tom Wilkinson (Dr. Howard Mierzwiak), Ryan Whitney (Young Joel), Debbon Ayer (Joel`s Mother), Amir Ali Said (Young Bully), Brian Price (Young Bully), Paul Litowsky (Young Bully)