Onder andere met: Antonio Banderas (Gregorio Cortez), Carla Gugino (Ingrid Cortez), Alexa Vega (Carmen Cortez), Daryl Sabara (Juni Cortez), Alan Cumming (Fegan Floop), Tony Shalhoub (Alexander Minion), Teri Hatcher (Ms. Gradenko), Cheech Marin (Felix Gumm), Robert Patrick (Mr. Lisp), Danny Trejo (Isidoro `Machete` Cortez), Mike Judge (Donnagon/Donnamight), Richard Linklater (Cool Spy), Guillermo Navarro (Pastor), Johnny Reno (Agent Johnny Robot), Shannon Shea (FoOglie #1/Flower), George Clooney (Devlin), Dick Clark (Financier)