Onder andere met: Naomi Watts (Ann Darrow), Jack Black (Carl Denham), Adrien Brody (Jack Driscoll), Thomas Kretschmann (Captain Englehorn), Colin Hanks (Preston), Andy Serkis (Kong/Lumpy), Evan Parke (Hayes), Jamie Bell (Jimmy), Lobo Chan (Choy), John Sumner (Herb), Craig Hall (Mike), Kyle Chandler (Bruce Baxter), Bill Johnson (Manny (as William Johnson)), Mark Hadlow (Harry), Geraldine Brophy (Maude)